Characterization of cortical thickness in DS is dependent on the control group

Surprisingly little is known about the developing brain in DS. Dividing cortical volume into thickness (CT) and surface area (SA) may be particularly fruitful, because CT and SA have differing genetic etiologies and developmental trajectories and both are linked to individual differences in intellectual functioning in TD individuals. As such, we aimed to examine differences in imaging findings for DS as compared to both peers who are the same chronological age (CA) as well as younger children with a similar mental age (MA). Results suggest that the pediatric brain in DS differs… Read More

Brain Development in Down Syndrome and Other Genetic Disorders

Dissociations in Cortical Morphometry in Youth with Down Syndrome: Evidence for Reduced Surface Area but Increased Thickness Caregiver Report of Executive Functioning in a Population-Based Sample of Young Children with Down Syndrome Everyday executive functions in Down syndrome from early childhood to young adulthood- evidence for both unique and shared characteristics compared to youth with sex chromosome trisomy A Case Study of Brain Morphometry inTriplets Discordant for Down Syndrome Abilities Related to Word Decoding in Youth with Down Syndrome  

Cognitive and Social Development in Children with Genetic Disorders

Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies. Executive Function in Young Males with Klinefelter (XXY) Syndrome with and without Comorbid Attention-Deficit / Hyperactivity Disorder Mapping the Stability of Human Brain Asymmetry across Five Sex-Chromosome Aneuploidies. Brain and behavior in 48, XXYY syndrome Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development A case-control study of brain structure and behavioral characteristics in 47,XXX syndrome

Links between brain and behavior in typical development

Trail making test performance in youth varies as a function of anatomical coupling between the prefrontal cortex and distributed cortical regions Distinct Cortical Correlates of Autistic versus Antisocial Traits in a Longitudinal Sample of Typically Developing Youth